Spinocerebellar ataxia-10 with paranoid schizophrenia

Spinocerebellar ataxia-10 with paranoid schizophrenia

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Spino-cerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder that is characterized by cerebellar ataxia, seizures and nystagmus with a fragmented pursuit.Schizophrenia has been reported with SCAs 1 and 2 yet in Tie Down Straps SCA 10, psychiatric manifestations are uncommon.We report a Hispanic family involving a father and his four children with SCA10 genetic mutation.Two of his children, a 20-year-old female and a 23-year-old male, presented with gradually progressive spino-cerebellar ataxia and paranoid schizophrenia.

Neurological examination revealed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia in both the cases.Additionally, they had a history of psychosis with destructive behavior, depression and paranoid delusions with auditory hallucinations.Serology and CSF studies were unremarkable and MRI brain revealed cerebellar volume Adjustment pull Pin loss.Ultimately, a test for ATAXIN-10 mutation was positive thus confirming the diagnosis of SCA10 in father and his four children.

We now endeavor to investigate the association between schizophrenia and SCA10.